辣椒素
葡萄糖稳态
TRPV1型
化学
胰岛素抵抗
碳水化合物代谢
糖尿病
血糖调节
内科学
内分泌学
药理学
平衡
医学
瞬时受体电位通道
受体
作者
Wanxia Liang,Yaqi Lan,Chengyu Chen,Mingyue Song,Jie Xiao,Qingrong Huang,Yong Cao,Chi Tang Ho,Muwen Lu
标识
DOI:10.1080/10408398.2021.1991883
摘要
Abnormal glucose homeostasis is linked to a variety of metabolic syndromes, such as insulin resistance, obesity, type-2 diabetes mellitus, hypertension and cardiovascular diseases. Maintenance of normal glucose homeostasis is important for the body to keep normal biological functions. As the major bioactive ingredient in chili peppers responsible for the pungent flavor, capsaicin has been reported to effectively improve glucose homeostasis with low cytotoxicity. In this review, the modulating effects of capsaicin on glucose homeostasis in cell models, animal models and human trials are summarized through both TRPV1 dependent and TRPV1 independent pathways. The relevant molecular mechanisms underlying its regulatory effects are also evaluated. Understanding the effects and mechanisms of capsaicin on glucose metabolism could provide theoretical evidence for its application in the food and pharmaceutical industries.
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