促炎细胞因子
体内
脂多糖
化学
体外
柠檬苦素
药理学
炎症
卡拉胶
消炎药
MAPK/ERK通路
生物化学
信号转导
医学
生物
免疫学
生物技术
作者
Ming Bian,Guo-Hua Gong,Lei Pang,Huanhuan Du,Chunmei Bai,Cheng‐Xi Wei,Zhe‐Shan Quan,Qianqian Ma
标识
DOI:10.1021/acs.jafc.1c04989
摘要
In this study, limonin derivatives were used to design new anti-inflammatory compounds with high pharmacological activity and low toxicity. A total of 23 new limonin derivatives were discovered, synthesized, and screened for their anti-inflammatory activity against lipopolysaccharide (LPS)-treated RAW 264.7 cells. Of them, compound f4 was found to be the most active, with a higher efficiency compared with limonin and celecoxib. Subsequently, we studied the mechanism underlying the activity of f4 and found that it inhibited proinflammatory cytokines by blocking the NF-κB/MAPK signaling pathway in LPS-treated RAW 264.7 cells as well as mice. In conclusion, f4 may be a promising anti-inflammatory lead compound.
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