硼
纳米材料
生物传感器
检出限
硼酸
材料科学
石墨烯
化学
纳米技术
色谱法
有机化学
作者
Siyu Luo,Meng Sha,Fei Tian,Xialian Li,Lei Fu,Yingqiu Gu,Lulu Qu,Guohai Yang,Chengzhou Zhu
标识
DOI:10.1016/j.cclet.2021.06.018
摘要
The rational design of nanozymes with superior activities is essential for improving bioassay performances. Herein, nitrogen and boron co-doped graphene nanoribbons (NB-GNRs) are prepared by a hydrothermal method using urea as the nitrogen source and boric acid as the boron source, respectively. The introduction of co-doped and edge structures provides high defects and active sites. The resultant NB-GNRs nanozymes show superior peroxidase-like activities to nitrogen-doped and boron-doped counterparts due to the synergistic effects. By taking advantage of their peroxidase-like activities, NB-GNRs are used for the first time to develop enzyme-linked immunosorbent assay for the detection of interleukin-6. The biosensors exhibit a high performance with a linear range from 0.001 ng/mL to 1000 ng/mL and a detection limit of 0.3 pg/mL. Due to their low cost and high stability, the proposed nanomaterials show great promise in biocatalysis, immunoassay development and environmental monitoring.
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