生物
糖酵解
组蛋白
表观遗传学
后生
细胞生物学
遗传学
生物化学
乙酰化
新陈代谢
DNA甲基化
基因
基因表达
作者
Xiaofeng Dai,Xinyu Lv,Erik W. Thompson,Kostya Ostrikov
标识
DOI:10.1016/j.tig.2021.09.009
摘要
Histone lactylation and acetylation compete for epigenetic modification of lysines and mark the levels of lactates and acetyl-CoA. Whether pyruvate is committed to lactate or acetyl-CoA generation as the outlet of glycolysis determines cell fate towards malignancy or not. Taking control over the glycolytic switch as marked by lactylation suggests novel therapeutic opportunities against cancers.
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