化学
对映选择合成
催化作用
试剂
立体选择性
有机化学
酒
组合化学
磷酸
对映体过量
对映体
作者
Mattia Lazzarotto,Peter Hartmann,Jakob Pletz,Ferdinand Belaj,Wolfgang Kroutil,Stefan E. Payer,Michael Fuchs
标识
DOI:10.1002/adsc.202100037
摘要
The substrate scope of the asymmetric allylation with zinc organyls catalyzed by 3,3-bis(2,4,6-triisopropylphenyl)-1,1-binaphthyl-2,2-diyl hydrogenphosphate (TRIP) has been extended to non-cyclic ester organozinc reagents and ketones. Tertiary chiral alcohols are obtained with ee's up to 94% and two stereogenic centers can be created. Compared to the previous lactone reagent the stereopreference switches almost completely, proving the fact that the nature of the organometallic compound is of immense importance for the asymmetry of the product.
科研通智能强力驱动
Strongly Powered by AbleSci AI