碳纳米管
化学
手性(物理)
对映体
生物分子
立体选择性
DNA
背景(考古学)
对映体药物
不对称碳
荧光
纳米技术
组合化学
对映选择合成
立体化学
有机化学
材料科学
生物化学
烷基
物理
催化作用
古生物学
生物
量子力学
手征对称破缺
Nambu–Jona Lasinio模型
夸克
作者
Zeus A. De los Santos,Zhiwei Lin,Ming Zheng
摘要
DNA-wrapped carbon nanotubes have been explored increasingly as sensitive near-infrared fluorescence probes for biomolecules. However, notably missing in previous studies is an inquiry on stereoselective interactions between DNA-wrapped carbon nanotubes and biomolecules. Here, enantiopure (+) and (-)(6,5), and (-)(8,3) as well as achiral (11,0) carbon nanotubes wrapped with specific resolving DNA sequences are used to demonstrate their stereoselective detection of amino acid enantiomers. Furthermore, stereoselective sensing abilities are found to be retained by dispersions containing a multitude of chiral nanotube structures. The fluorescence response profiles of six different DNA-wrapped carbon nanotube dispersions to nine standard amino acids, and their enantiomers, demonstrate that DNA-wrapped carbon nanotubes are exquisitely sensitive to the stereoconfiguration and side-chain functionality of amino acids in a manner that is dependent on both DNA sequence and nanotube chirality. Implications of our findings are discussed in the context of developing a machine learning-aided multiplexed biosensing scheme called a molecular perceptron.
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