化学
磺胺
炔基化
配体(生物化学)
组合化学
氨基酸
衍生化
催化作用
铜
有机化学
受体
高效液相色谱法
生物化学
作者
Ryogo Takai,Daisuke Shimbo,Norio Tada,Akichika Itoh
标识
DOI:10.1021/acs.joc.1c00101
摘要
Ynamides are versatile building blocks in organic synthesis. However, the synthesis of amino acid-derived ynamides is difficult but in high demand. Herein, we disclose the copper-catalyzed Csp-N coupling of sulfonamide, including amino acid and peptide derivatives, to give ynamides by using alkynyl benziodoxolones with broad functional group tolerance under mild reaction conditions. The electron-rich bipyridine as a ligand and ethanol as solvent were used for the success of this reaction. The usefulness of the obtained amino acid-derived ynamide as building block was showcased by further derivatization to unique amino acid derivatives. A control experiment to elucidate the mechanistic insight was also described.
科研通智能强力驱动
Strongly Powered by AbleSci AI