Fabrication design, process technologies, and convolutions in the scale-up of nanotherapeutic delivery systems

Nanoformulations-based research has always been driven by the factors such as stability of drug within the carrier, prolonged shelf life, and cost-effective production design. It is needless to argue why most of the techniques employed for development of nanoformulations are often adapted around the physicochemical features of a particular drug to be encapsulated. However, such techniques only realize the tenacity for small scale preparation, but flounders upon while scale-up. Therefore, for the successful translation of a nanoproduct from bench to bedside, it is imperative to reduce the plethora of convolutions involved in manufacturing steps and simplify the design of nanotechnological processes into a one-step industrial scale-up solution with assistance of characterization techniques. The present chapter intends to recapitulate the technological advancements in the design of industrial scale technologies for the pilot scale production of nanoformulations (nanoliposomes, nanocrystals, nanoparticles, nanosuspensions, nanoemulsions, SNEDDS/SMEDDS) as well as to address the pitfalls of small scale research approaches (with potential to commercialization) in order to facilitate cost-effective design, maximum viability, stability, quality control, and therapeutic efficacy for better patient compliance.