过剩2
餐后
体内
葡萄糖转运蛋白
生物信息学
体外
化学
水解
生物化学
生物
内分泌学
胰岛素
生物技术
基因
作者
Luis Mojica,Elvira González de Mejía,María Ángeles Granados‐Silvestre,Mészáros Márta
标识
DOI:10.1016/j.jff.2017.02.006
摘要
The objective was to evaluate the in silico, in vitro and in vivo effects of a black bean hydrolyzed protein isolate (HPI) and its pure peptides on glucose absorption. By interacting with their protein motif, pure peptides blocked glucose transporters GLUT2 and SGLT1. HPI (10 mg/mL) reduced formation of intracellular oxygen reactive species by 71%. Glucose absorption decreased 21.5% after 24 h treatment when using the Caco-2 cell model. Oral glucose tolerance test in rats showed a 24.5% decrease on postprandial glucose (p < 0.05) (50 mg HPI /kg BW). In the hyperglycemic rat model, HPI caused a reduction of blood glucose, in a dose-dependent manner. The lowest fasting glucose was found in rats receiving 150 and 200 mg/kg BW/day HPI, (p < 0.05). The black bean HPI is an inexpensive food source of bioactive compounds that could be used in the management of blood glucose.
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