化学
马尔科夫尼科夫法则
烯烃
激进的
吡啶
分子间力
烷基化
选择性
组合化学
三乙基硼烷
有机化学
区域选择性
药物化学
光化学
分子
催化作用
作者
Allyson J Boyington,Martin-Louis Y. Riu,Nathan T. Jui
摘要
The intermolecular alkylation of pyridine units with simple alkenes has been achieved via a photoredox radical mechanism. This process occurs with complete regiocontrol, where single-electron reduction of halogenated pyridines regiospecifically yields the corresponding radicals in a programmed fashion, and radical addition to alkene substrates occurs with exclusive anti-Markovnikov selectivity. This system is mild, tolerant of many functional groups, and effective for the preparation of a wide range of complex alkylpyridines.
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