胆固醇逆向转运
ABCA1
清道夫受体
分解代谢
胆固醇
ATP结合盒运输机
运输机
高密度脂蛋白
肝X受体
化学
脂蛋白
载脂蛋白E
生物化学
内科学
内分泌学
生物
核受体
新陈代谢
医学
基因
疾病
转录因子
作者
Guang-xin Dong,Wenwen Li,Ruo-zhu Wang,Wenjun Zou,Zhendong Zhong,Bogang Li
标识
DOI:10.1097/fjc.0000000000000500
摘要
Abstract: Di'ao Xinxuekang (XXK) is an herbal product in China and the Netherlands that has been clinically shown to attenuate atherosclerosis; however, the underlying antiatherosclerotic mechanism remains unclear. Because of its role in cholesterol homeostasis, reverse cholesterol transport (RCT) is a potential target for these beneficial effects. This study investigated the effects of XXK on RCT and related proteins. After treating ApoE-deficient mice with XXK for 8 weeks, we observed an increase in the expression level of ATP-binding cassette transporter A1 and ATP-binding cassette transporter G1, which in turn stimulated cholesterol efflux and reduced aortic atherosclerotic lesion area. XXK also increased high-density lipoprotein (HDL) synthesis by modulating the peroxisome proliferator–activated receptor γ/liver X receptor α/ATP-binding cassette transporter A1 pathway and promoted HDL maturity by increasing serum lecithin–cholesterol acyltransferase. In addition, XXK improved the selective uptake of HDL-cholesteryl ester by increasing the expression of scavenger receptor class B type I. This is the first study to show that XXK confers a regulation of RCT, at least in part, by improving HDL synthesis, maturation, and catabolism.
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