钙蛋白酶
溃疡性结肠炎
医学
乳铁蛋白
免疫学
弹力素
CD64
S100A8型
炎症性肠病
炎症
中性粒细胞弹性蛋白酶
结肠炎
中性粒细胞胞外陷阱
生物标志物
髓过氧化物酶
疾病
病理
流式细胞术
生物
生物化学
遗传学
作者
Daniel Muthas,Anna Reznichenko,Clare A. Balendran,Gerhard Böttcher,Ib Groth Clausen,Carina Kärrman Mårdh,Tomas Ottosson,Mohib Uddin,Thomas T. MacDonald,Silvio Danese,Mark Berner Hansen
标识
DOI:10.1080/00365521.2016.1235224
摘要
This review article describes the role of neutrophils in mucosal injury and the resulting crypt abscesses characteristic of ulcerative colitis. We also review selected biomarkers for monitoring neutrophil presence and activity in the mucosa as well as their potential as therapeutic targets.We have collated and selectively reviewed data on the most prominent well-established and emerging neutrophil-related biomarkers and potential therapeutic targets (calprotectin, lactoferrin, CXCR1, CXCR2, MMP-9, NGAL, elafin, HNE, pANCAs, MPO, CD16, CD177, CD64, HNPs, SLPI and PTX3) in ulcerative colitis.Systemic and intestinal neutrophil activity increases substantially in active ulcerative colitis, driving tissue damage and extra-intestinal manifestations. Calprotectin is a robust neutrophil and disease biomarker, and a few neutrophil-related targets are being clinically explored as therapeutic targets.We propose that targeting neutrophils and their inflammatory mediators per se is an opportunity that should be explored to identify new effective medical therapies. The overall clinical goal for neutrophil-targeted therapy will be to modulate, but not completely silence, neutrophil activity, thereby abolishing the destructive inflammation with associated acute and chronic tissue damage without compromising host-defense.
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