连续流动
芳基
光催化
化学
流动化学
流量(数学)
组合化学
光化学
有机化学
催化作用
生化工程
数学
烷基
几何学
工程类
作者
Romain Lapierre,Thi Minh Thi Le,Bruno Schiavi,Damien Thévenet,M. Bazin,Ryan Buzdygon,Philippe Jubault,Thomas Poisson
标识
DOI:10.1021/acs.oprd.2c00379
摘要
Herein we disclose our study toward the synthesis of aryl phosphonates using either photocatalytic conditions or a photoinduced process. First, a phosphonylation reaction catalyzed by a copper complex was developed in batch, but unfortunately, it was not efficient under continuous flow. Alternatively, a photoinduced phosphonylation reaction was developed in continuous flow with a moderate efficiency. Finally, to enhance the yields observed under the continuous flow conditions for the scale-up, a complementary approach using another commercially available photoreactor was suggested to tackle the modest productivity observed in continuous flow.
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