内源性逆转录病毒
先天免疫系统
医学
心肌炎
表观遗传学
生物
病毒学
免疫学
免疫系统
遗传学
基因
基因组
内科学
作者
Junhao Xiong,Shasha Zhang,Zilong Geng,Jun‐Tao Lin,Kang Cheng,Huan Hu,Yuze Wang,Xing Liu,Yang Sheng,Ping Yang,Yige Li,Shuo Wu,Xiao Cheng,Yelan Li,Aijun Sun,Alex F. Chen,Dao Wen Wang,Chen Chen,Yan Zhang,Gengze Wu
出处
期刊:Circulation
[Lippincott Williams & Wilkins]
日期:2025-08-18
卷期号:152 (13): 939-956
被引量:3
标识
DOI:10.1161/circulationaha.125.074845
摘要
ERV resurgence is a specific molecular trait of HF, driven by TRIM28 depletion in cardiomyocytes. ERV resurgence activates the innate immune TLR7/9-NF-κB pathway and induces myocarditis and HF. Inception of ERVs and the ERV-mediated immune pathway confers cardiac protection. These results identify TRIM28-ERV-TLR7/9-NF-κB as a target for therapeutic management of myocarditis and HF.
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