Combined Flt3L and CD40 agonism restores dendritic cell–driven T cell immunity in pancreatic cancer

T cell expansion, and in turn, T cell-derived IFN-γ enhanced cDC1 survival. Nevertheless, Flt3L and CD40 agonism increased regulatory T cells through the activation of cDC2s, dampening immunity. These findings advocate further exploration of DC-centered approaches to enhance antitumor immunity in PDAC.