Patient and Operative Risk Factors for Subsequent Knee Arthroplasty After Primary Anterior Cruciate Ligament Reconstruction: A Cohort Study of 52,222 Patients

Increasing age was the strongest risk factor for subsequent knee arthroplasty in patients who have undergone prior ACLR. Patients should be counseled that undergoing ACLR with allograft had a 2 times higher risk of future knee arthroplasty compared with patellar tendon autograft. Additional independent risk factors identified included female sex, increasing BMI, a history of hypertension or other neurological disorders, trauma-related injury compared with sports injury, concomitant chondral injury, and revision surgery, ipsilateral reoperation, or contralateral surgery during follow-up.