阶段(地层学)
危险系数
单变量分析
肺
腺癌
队列
多元分析
回顾性队列研究
肿瘤科
肺癌
医学
胃肠病学
比例危险模型
总体生存率
内科学
癌症
生物
置信区间
古生物学
作者
David Laville,Anne-Laure Désage,P. Fournel,Sophie Bayle-Bleuez,Chaouki Neifer,Tiphanie Picot,Abdulrazzak Sulaiman,Olivier Tiffet,Fabien Forest
标识
DOI:10.1097/pas.0000000000002188
摘要
In recent years, the concept of spread through air spaces (STAS) has been discussed as an adverse prognostic factor for lung cancer. The aim of our study is to clarify the prognostic role of STAS in relation to the main recognized prognostic factors in a retrospective cohort of 330 European patients who underwent stages I to III lung adenocarcinoma resection. On univariate analysis, the presence of STAS was related to progression-free survival (PFS; hazard ratio [HR]: 1.48; 95% CI: 1.02-2.19; P = 0.038) and overall survival (OS; HR: 1.61; 95% CI: 1.03-2.52; P = 0.50). On multivariate analysis, STAS was related to PFS (HR: 1.51; 95% CI: 1.00-2.17; P = 0.050) and to OS (HR: 1.67; 95% CI: 1.00-2.81; P = 0.050). We showed that the presence of STAS was associated with lower PFS, equivalent to the next pathologic T stage, especially the median PFS of T3 stages without STAS was at 62.8 months while the median PFS of T3 stages with STAS was at 15.7 months, closer to the median PFS of 17.4 months in T4 stages. To conclude, STAS is an independent prognostic factor of PFS in this European cohort and is close to significance for OS. We suggest that the presence of STAS might lead to an upstaging of lung adenocarcinoma.
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