前额叶腹内侧皮质
强啡肽
神经科学
心理学
神经网络
前额叶皮质
受体
生物
阿片肽
类阿片
认知
生物化学
作者
Huikun Wang,Rodolfo Flores,Héctor E. Yarur,Aaron Limoges,Héctor Bravo-Rivera,Sanne M. Casello,Niharika Loomba,Juan Enríquez-Traba,Miguel Arenivar,Q Wang,Robert P. Ganley,Charu Ramakrishnan,Lief E. Fenno,Yoon Kim,Karl Deisseroth,Grace Or,Chunyang Dong,Mrinalini Hoon,Lin Tian,Hugo A. Tejeda
标识
DOI:10.1101/2024.01.08.574700
摘要
Summary Prefrontal cortical (PFC) circuits provide top-down control of threat reactivity. This includes ventromedial PFC (vmPFC) circuitry, which plays a role in suppressing fear-related behavioral states. Dynorphin (Dyn) has been implicated in mediating negative affect and mal-adaptive behaviors induced by severe threats and is expressed in limbic circuits, including the vmPFC. However, there is a critical knowledge gap in our understanding of how vmPFC Dyn-expressing neurons and Dyn transmission detect threats and regulate expression of defensive behaviors. Here, we demonstrate that Dyn cells are broadly activated by threats and release Dyn locally in the vmPFC to limit passive defensive behaviors. We further demonstrate that vmPFC Dyn-mediated signaling promotes a switch of vmPFC networks to a fear-related state. In conclusion, we reveal a previously unknown role of vmPFC Dyn neurons and Dyn neuropeptidergic transmission in suppressing defensive behaviors in response to threats via state-driven changes in vmPFC networks. Highlights ● vmPFC Dyn neurons are activated by threats and threat-predictive cues ● Characterization of a genetically-encoded kappa-opioid receptor sensor ● vmPFC Dyn neurons rapidly release Dyn in response to threats and their predictors ● vmPFC Dyn signaling opposes threat-induced passive defensive behaviors ● Dyn signaling promotes threat-evoked state transitions in vmPFC networks
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