Copper-Catalyzed Enantioselective Radical Esterification of Propargylic C−H Bonds

The copper-catalyzed enantioselective radical esterification of propargylic C−H bonds with tert-butyl peroxybenzoate (TBPB) as oxidizing agent and oxygenated nucleophile has been reported. This variant of the Kharasch-Sosnovsky oxidation allows for the asymmetric esterification of open-chain carbon radicals without excessive amounts of alkyne substrates under mild reaction conditions, achieving a one-step conversion from simple alkynes to chiral propargylic esters.