生物
H5N1亚型流感病毒
MDA5型
病毒学
干扰素
信号转导
先天免疫系统
钻机-I
细胞生物学
甲型流感病毒
跨膜蛋白
跨膜结构域
病毒
免疫系统
受体
基因
核糖核酸
遗传学
RNA干扰
作者
Zuxian Chen,Bingbing Zhao,Yingying Wang,Youwei Du,Siyu Feng,Junsheng Zhang,Luxiang Zhao,Weiqiang Li,Yangbao Ding,Peirong Jiao
标识
DOI:10.1016/j.jia.2023.12.040
摘要
Type I interferon (IFN)-mediated innate immune responses represent the first line of host defense against viral infection. However, the molecular mechanisms by which avian influenza virus (AIV) inhibits type I IFN production in ducks are not well understood. Here, we first found that the polymerase basic 2 (PB2) protein of H5N1 subtype AIV inhibited the type I IFN responses by targeting duck mitochondrial antiviral signaling protein (MAVS). We further demonstrated that H5N1-PB2 bound to the △transmembrane (△TM) domain of duck MAVS, and the polymerase basic 1 (PB1) binding domain (PBD) and RNA binding nuclear import domain (RND) of H5N1-PB2 interacted with MAVS to inhibit type I IFN expression in ducks. Collectively, our findings contribute to understanding the molecular mechanism by which AIV proteins regulate the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) signaling pathway to evade host antiviral immune responses in ducks.
科研通智能强力驱动
Strongly Powered by AbleSci AI