归巢(生物学)
干细胞
离体
造血
脐带血
移植
造血干细胞移植
免疫学
生物
医学
体内
内科学
细胞生物学
生物技术
生态学
作者
Bin Guo,Xinxin Huang,Yandan Chen,Hal E. Broxmeyer
标识
DOI:10.1007/978-981-99-7471-9_6
摘要
Cord blood (CB) has been proven to be an alternative source of haematopoietic stem cells (HSCs) for clinical transplantation and has multiple advantages, including but not limited to greater HLA compatibility, lower incidence of graft-versus-host disease (GvHD), higher survival rates and lower relapse rates among patients with minimal residual disease. However, the limited number of HSCs in a single CB unit limits the wider use of CB in clinical treatment. Many efforts have been made to enhance the efficacy of CB HSC transplantation, particularly by ex vivo expansion or enhancing the homing efficiency of HSCs. In this chapter, we will document the major advances regarding human HSC ex vivo expansion and homing and will also discuss the possibility of clinical translation of such laboratory work.
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