自愈水凝胶
透明质酸
材料科学
伤口愈合
富血小板血浆
明胶
细胞外基质
甲基丙烯酸酯
生物医学工程
伤口敷料
基质(化学分析)
体内
再生(生物学)
纳米技术
血小板
化学
高分子化学
复合材料
外科
细胞生物学
聚合
生物化学
聚合物
医学
免疫学
解剖
生物技术
生物
作者
Neng Ding,Xinxin Fu,Qixiang Gui,Minjuan Wu,Zhenchuan Niu,Antong Du,Jinyue Liu,Honglu Wu,Qianqian Wang,Xuezheng Yue,Lie Zhu
标识
DOI:10.1002/adhm.202303192
摘要
Abstract Exploring the preparation of multifunctional hydrogels from a bionic perspective is an appealing strategy. Here, a multifunctional hydrogel dressing inspired by the characteristics of porous extracellular matrix produced during Acomys wound healing is prepared. These dressings are printed by digital light processing printing of hydrogels composed of gelatin methacrylate, hyaluronic acid methacrylate, and pretreated platelet‐rich plasma (PRP) to shape out triply periodic minimal surface structures, which are freeze‐dried for long‐term storage. These dressings mimic the porous extracellular matrix of Acomys, while the freeze‐drying technique effectively extends the storage duration of PRP viability. Through in vivo and in vitro experiments, the biomimetic dressings developed in this study modulate cell behavior and facilitate wound healing. Consequently, this research offers a novel approach for the advancement of regenerative wound dressings.
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