生物
表观遗传学
DNA甲基化
肥胖
生命历程法
干预(咨询)
生物信息学
遗传学
内分泌学
发展心理学
心理学
基因
基因表达
精神科
作者
Anat Yaskolka Meir,Huan Yun,Meir J. Stampfer,Liming Liang,Frank B. Hu
出处
期刊:Epigenomics
[Future Medicine]
日期:2023-10-01
卷期号:15 (19): 991-1015
标识
DOI:10.2217/epi-2023-0172
摘要
Obesity is a complex multifactorial condition that often manifests in early life with a lifelong burden on metabolic health. Diet, including pre-pregnancy maternal diet, in utero nutrition and dietary patterns in early and late life, can shape obesity development. Growing evidence suggests that epigenetic modifications, specifically DNA methylation, might mediate or accompany these effects across life stages and generations. By reviewing human observational and intervention studies conducted over the past 10 years, this work provides a comprehensive overview of the evidence linking nutrition to DNA methylation and its association with obesity across different age periods, spanning from preconception to adulthood and identify future research directions in the field.
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