咪唑酯
沸石咪唑盐骨架
材料科学
脚手架
再生(生物学)
地塞米松
体内
组织工程
骨组织
生物医学工程
金属有机骨架
纳米技术
有机化学
化学
医学
内科学
生物技术
生物
细胞生物学
吸附
作者
Zheng-Yang Chen,Rui-Deng Wang,Shilong Su,Youliang Hao,Fang Zhou
摘要
Bone defects have attracted increasing attention in clinical settings. To date, there have been no effective methods to repair defective bones. Balsa wood aerogels are considered as an excellent source of chemicals for chemical modification to facilitate the in situ immobilization of zeolitic imidazolate framework-8. Furthermore, dexamethasone has received considerable attention for bone tissue engineering. In this study, for the first time, a simple but effective one-pot method for developing a novel zeolitic imidazolate framework-8 with different concentrations of dexamethasone was developed. These findings illustrate that the novel scaffold has a significant positive impact on osteogenic differentiation in vitro and repairs defects in vivo, suggesting that it can be used in bone tissue engineering.
科研通智能强力驱动
Strongly Powered by AbleSci AI