化学
小学(天文学)
有机化学
三氟甲基化
反应条件
组合化学
药物化学
催化作用
烷基
物理
天文
三氟甲基
作者
Yisong Tang,Meng Huang,Liang Jiang,Xiaolin Zhang,Shaojun Zheng,Yong Yang,Xiao Yun Chen
标识
DOI:10.1002/chem.202302249
摘要
Abstract A novel one‐pot two‐step multicomponent reaction has been achieved for the preparation of β ‐CF 3 enamines by using different aliphatic amines, propiolates, and CF 3 SO 2 Na as starting material. In this protocol, various aliphatic amines including primary amines, cyclic or acyclic secondary amines were demonstrated to be good coupling partners, and different β ‐CF 3 enamines were obtained in moderate to good yields. Among them, the primary aliphatic amines only gave pure ( E )‐ β ‐CF 3 enamines as products. The synthetic utility of the MCRs strategy was further demonstrated by mild conditions, gram‐scale synthesis and natural sunlight‐induced protocol. Preliminary mechanistic studies suggest that this trifluoromethylation of C(sp 2 )−H involves radical process.
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