脊髓损伤
神经干细胞
医学
干细胞
脚手架
神经科学
脊髓
生物
生物医学工程
遗传学
作者
Grace Hey,Matthew Willman,Aashay Patel,Michael Goutnik,Jonathan Willman,Brandon Lucke‐Wold
出处
期刊:Biomechanics
[MDPI AG]
日期:2023-08-01
卷期号:3 (3): 322-342
被引量:7
标识
DOI:10.3390/biomechanics3030028
摘要
Spinal cord injury (SCI) is a profoundly debilitating yet common central nervous system condition resulting in significant morbidity and mortality rates. Major causes of SCI encompass traumatic incidences such as motor vehicle accidents, falls, and sports injuries. Present treatment strategies for SCI aim to improve and enhance neurologic functionality. The ability for neural stem cells (NSCs) to differentiate into diverse neural and glial cell precursors has stimulated the investigation of stem cell scaffolds as potential therapeutics for SCI. Various scaffolding modalities including composite materials, natural polymers, synthetic polymers, and hydrogels have been explored. However, most trials remain largely in the preclinical stage, emphasizing the need to further develop and refine these treatment strategies before clinical implementation. In this review, we delve into the physiological processes that underpin NSC differentiation, including substrates and signaling pathways required for axonal regrowth post-injury, and provide an overview of current and emerging stem cell scaffolding platforms for SCI.
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