泌尿系统
医学
增生
前列腺
泌尿科
前列腺癌
下尿路症状
尿
内科学
微生物群
肠道菌群
胃肠病学
生理学
癌症
生物
免疫学
生物信息学
作者
Antonio C. H. Mariotti,Vitor Heidrich,Lilian Tiemi Inoue,Eduarda Raísa Coser,Eugene Santos,Hugo dos Santos,Carolina Rocha,Paula Fontes Asprino,Fabiana Bettoni,Diogo Assed Bastos,Denis Leonardo Fontes Jardim,Anamaria A. Camargo,Marco Antônio Arap
出处
期刊:The Prostate
[Wiley]
日期:2023-11-13
卷期号:84 (3): 285-291
摘要
Abstract Background The urinary microbiota of patients with benign prostatic hyperplasia (BPH) has been associated with lower urinary tract symptoms (LUTS), however, little is known about urinary microbiota correlations with clinicopathological parameters associated with BPH. Here, we investigate associations between the urinary microbiota and clinical parameters of patients with BPH undergoing surgery. Methods Forty‐one patients with BPH undergoing surgery were recruited from two medical centers. Catheterized urine specimens were collected and the microbiota was characterized by 16S rRNA gene sequencing. Patients were segregated into two groups according to each clinical parameter and differences in urinary microbiota diversity and composition were evaluated. Results Higher prostate weight and prostate‐specific antigen (PSA) levels were associated with higher alpha diversity in the urinary microbiota of BPH patients. At the specific microbe level, we found that the greater the prostatic weight, the lower the relative abundance of Streptococcus , while the greater the PSA levels, the higher the abundance of Lactobacillus . Treatment with 5‐α‐reductase inhibitor was associated with overall urinary microbiota composition, in part due to a higher abundance of Corynebacterium and Anaerococcus in this group. Conclusions We demonstrated that the urinary microbiota of BPH patients is associated with clinicopathological features, paving the way for larger studies in which causality between urinary microbiota and BPH can be appropriately explored.
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