Clinical Validation of Face‐Fit Surface‐Lighting Micro Light‐Emitting Diode Mask for Skin Anti‐Aging Treatment

Abstract Photobiomodulation therapy based on micro light‐emitting diodes (µLEDs) holds remarkable potential for the beauty industry. Here, a cosmetically effective face‐fit surface‐lighting µLED mask for skin anti‐aging is introduced. The face‐conformable mask enables deep tissue treatment through proximal light irradiation, with a 3D origami structure capable of adapting to complex facial contours with closed adherence. A blister‐assisted laser transfer achieves rapid and accurate µLEDs transfer at a high throughput of 50 chips per second, facilitating a mass‐producible and large‐area process. Finally, clinical trials demonstrate significant improvements in elasticity, sagging, and wrinkles across six facial areas, with a maximum enhancement of 340% in deep skin elasticity of the perioral area compared to the conventional LED mask group.