Copper-Catalyzed Electrophilic Amination of ArylZinc Pivalates mediated by N-based Hypervalent Iodine(III) Reagents

We describe a new Cu-catalyzed electrophilic amination of stable polyfunctional organozinc compounds using new hypervalent iodine reagents bearing transferable alkyl and aryl amines. A wide range of aryl, heteroaryl and alkyl amines were prepared, and the method applied to the synthesis of chloroquine drug. The mechanism of the reaction was investigated by DFT calculations.