Study on Chemical Components from Derris taiwaniana and Their Lung Epithelial Cell Protect Effects

The ethanol extract of roots of Derris taiwaniana gave two undescribed compounds, 3,3'-dimethoxy-5'-hydroxystilbene-4-O-β-apiofuranosyl-(1→6)-β-D-glucopyranoside (1) and 4',5-dihydroxy-3'-methoxyisoflavone-7-O-β-apiofuranosyl-(1→6)-β-D-glucopyranoside (2), along with thirty known components. Among them, compounds 14, 16-17, 23, 26-32 were isolated from this genus for the first time. Their structures were established based on physico-chemical properties and spectroscopic data, the lung epithelial cell protective effects were evaluated using NNK-induced MLE-12 cells. Among them, 2α,3α-epoxy-5,7,3',4'-tetrahydroxyflavan-(4β-8-catechin) (30) showed the best significant protective effect, speculated to be the key component of D. taiwaniana that plays a protective role in lung epithelial cells.