Recent Advances in Hydrogel‐Based Strategies for Promoting Wound Healing

ABSTRACT Wound healing is a dynamic and continuous process. Hydrogels, as three‐dimensional polymeric networks, have emerged as versatile platforms for tissue repair due to their tunable mechanical properties, environmental responsiveness, and diverse application forms. Despite extensive research, the mechanisms by which hydrogel properties regulate cellular interactions and tissue regeneration remain poorly understood. While hydrogels have demonstrated good biocompatibility in animal models, further research is needed to translate these findings to human chronic wound healing. Existing reviews largely focus on material characteristics or single bioactive agents, with limited discussion of integrated multifunctional design strategies. Recent studies demonstrate that diversified hydrogel designs and functionalities can effectively enhance wound healing, including accelerated healing and disease‐specific applications. This review systematically summarizes these advances, emphasizing the relationships between hydrogel properties, their functional roles in tissue repair, and their application across pathological contexts, providing insights to guide the rational design and clinical translation of next‐generation hydrogel‐based wound dressings.