Coumarins from Sarcandra glabra (Thunb.) Nakai and Acetylcholinesterase Inhibiting Activity

Abstract Nine coumarins including a pair of new enantiomers (1a/1b) and seven known compounds (2–8) were isolated from Sarcandra glabra (Thunb.) Nakai. Among them, compounds 1a and 1b were naturally occurring coumarin‐phenylpropanoid conjugate enantiomers. Their structures were identified by NMR and ECD calculations. Compounds 1–8 were tested for acetylcholinesterase (AchE) inhibiting activity. The results of the enzymology experiment showed that compound 3 demonstrated obvious AchE inhibitory activity which showed the IC50 value of 1.982±0.003 μM, and the binding sites were predicted by molecular docking.