氰化
化学
区域选择性
脂环化合物
胺气处理
取代基
酮
有机化学
组合化学
催化作用
作者
Fuchao Yu,Daniel A. Valles,Weijie Chen,Scott D. Daniel,Ion Ghiviriga,Daniel Seidel
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-08-29
卷期号:24 (35): 6364-6368
被引量:6
标识
DOI:10.1021/acs.orglett.2c02148
摘要
Secondary alicyclic amines are converted to α-aminonitriles via addition of TMSCN to their corresponding imines, intermediates that are produced in situ via the oxidation of amine-derived lithium amides with simple ketone oxidants. Amines with an existing α-substituent undergo regioselective α'-cyanation even if the C-H bonds at that site are less activated. Amine α-arylation can be combined with α'-cyanation to generate difunctionalized products in a single operation.
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