谷氨酸的
加巴能
神经科学
光遗传学
感觉系统
价(化学)
心理学
谷氨酸受体
生物
化学
抑制性突触后电位
生物化学
受体
有机化学
作者
Cuiyu Xiao,Jinxing Wei,Guangwei Zhang,Can Tao,Junxiang Huang,Li Shen,Ian R. Wickersham,Huizhong W. Tao,Li I. Zhang
出处
期刊:Neuron
[Elsevier]
日期:2023-05-01
卷期号:111 (9): 1486-1503.e7
被引量:5
标识
DOI:10.1016/j.neuron.2023.02.012
摘要
Extracting the valence of environmental cues is critical for animals' survival. How valence in sensory signals is encoded and transformed to produce distinct behavioral responses remains not well understood. Here, we report that the mouse pontine central gray (PCG) contributes to encoding both negative and positive valences. PCG glutamatergic neurons were activated selectively by aversive, but not reward, stimuli, whereas its GABAergic neurons were preferentially activated by reward signals. The optogenetic activation of these two populations resulted in avoidance and preference behavior, respectively, and was sufficient to induce conditioned place aversion/preference. Suppression of them reduced sensory-induced aversive and appetitive behaviors, respectively. These two functionally opponent populations, receiving a broad range of inputs from overlapping yet distinct sources, broadcast valence-specific information to a distributed brain network with distinguishable downstream effectors. Thus, PCG serves as a critical hub to process positive and negative valences of incoming sensory signals and drive valence-specific behaviors with distinct circuits.
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