先天性淋巴细胞
免疫学
生物
背景(考古学)
先天免疫系统
免疫
肺
免疫系统
医学
古生物学
内科学
作者
Pauline Loos,Jérôme Baiwir,Céline Maquet,Justine Javaux,R Sandor,François Lallemand,Thomas Marichal,Bénédicte Machiels,Laurent Gillet
出处
期刊:Science immunology
[American Association for the Advancement of Science (AAAS)]
日期:2023-02-24
卷期号:8 (80)
被引量:3
标识
DOI:10.1126/sciimmunol.abl9041
摘要
Immunological dysregulation in asthma is associated with changes in exposure to microorganisms early in life. Gammaherpesviruses (γHVs), such as Epstein-Barr virus, are widespread human viruses that establish lifelong infection and profoundly shape host immunity. Using murid herpesvirus 4 (MuHV-4), a mouse γHV, we show that after infection, lung-resident and recruited group 2 innate lymphoid cells (ILC2s) exhibit a reduced ability to expand and produce type 2 cytokines in response to house dust mites, thereby contributing to protection against asthma. In contrast, MuHV-4 infection triggers GM-CSF production by those lung ILC2s, which orders the differentiation of monocytes (Mos) into alveolar macrophages (AMs) without promoting their type 2 functions. In the context of γHV infection, ILC2s are therefore essential cells within the pulmonary niche that imprint the tissue-specific identity of Mo-derived AMs and shape their function well beyond the initial acute infection.
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