自愈水凝胶
海藻酸钠
材料科学
脚手架
复合数
生物医学工程
组织工程
聚合物
粘附
3d打印
钠
化学工程
纳米技术
复合材料
高分子化学
工程类
冶金
作者
Xulin Hu,Zhen Zhang,Haoming Wu,Shuhao Yang,Weiming Zhao,Lufeng Che,Yao Wang,Jian Cao,Kainan Li,Zhiyong Qian
出处
期刊:Biomaterials advances
日期:2023-09-01
卷期号:152: 213501-213501
被引量:7
标识
DOI:10.1016/j.bioadv.2023.213501
摘要
In recent years, hydrogels have been widely used in the biomedical field as materials with excellent bionic structures and biological properties. Among them, the excellent comprehensive properties of natural polymer hydrogels represented by sodium alginate have attracted the great attention of researchers. At the same time, by physically blending sodium alginate with other materials, the problems of poor cell adhesion and mechanical properties of sodium alginate hydrogels were directly improved without chemical modification of sodium alginate. The composite blending of multiple materials can also improve the functionality of sodium alginate hydrogels, and the prepared composite hydrogel also has a larger application field. In addition, based on the adjustable viscosity of sodium alginate-based hydrogels, sodium alginate-based hydrogels can be loaded with cells to prepare biological ink, and the scaffold can be printed out by 3D printing technology for the repair of bone defects. This paper first summarizes the improvement of the properties of sodium alginate and other materials after physical blending. Then, it summarizes the application progress of sodium alginate-based hydrogel scaffolds for bone tissue repair based on 3D printing technology in recent years. Moreover, we provide relevant opinions and comments to provide a theoretical basis for follow-up research.
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