亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Chemotherapy-induced gut microbiome disruption, inflammation, and cognitive decline in female patients with breast cancer

认知功能衰退 微生物群 认知 化疗 乳腺癌 医学 内科学 免疫学 肠道菌群 炎症 癌症 肿瘤科 生物 生物信息学 痴呆 疾病 精神科
作者
Lauren Otto,Corena V. Grant,Ashley A. Lahoud,Olivia Wilcox,Lindsay Strehle,Brett R. Loman,Seth Adarkwah Yiadom,Melina Seng,Nicklaus Halloy,Kathryn L.G. Russart,Kristen M. Carpenter,Erica Dawson,S.D. Sardesai,Nicole Williams,Margaret E. Gatti‐Mays,Daniel G. Stover,P.K. Sudheendra,Robert Wesolowski,Janice K. Kiecolt‐Glaser,Michael T. Bailey
出处
期刊:Brain Behavior and Immunity [Elsevier BV]
卷期号:120: 208-220 被引量:7
标识
DOI:10.1016/j.bbi.2024.05.039
摘要

Chemotherapy is notorious for causing behavioral side effects (e.g., cognitive decline). Notably, the gut microbiome has recently been reported to communicate with the brain to affect behavior, including cognition. Thus, the aim of this clinical longitudinal, observational study was to determine whether chemotherapy-induced disruption of the gut microbial community structure relates to cognitive decline and circulating inflammatory signals. Fecal samples, blood, and cognitive measures were collected from 77 patients with breast cancer before, during, and after chemotherapy. Chemotherapy altered the gut microbiome community structure and increased circulating TNF-α. Both the chemotherapy-induced changes in microbial relative abundance and decreased microbial diversity were related to elevated circulating pro-inflammatory cytokines, TNF-α and IL-6. Participants reported subjective cognitive decline during chemotherapy, which was not related to changes in the gut microbiome or inflammatory markers. In contrast, a decrease in overall objective cognition was related to a decrease in microbial diversity, independent of circulating cytokines. Stratification of subjects, via a reliable change index based on all 4 objective cognitive tests, identified objective cognitive decline in 35% of the subjects. Based on a differential microbial abundance analysis, those characterized by cognitive decline had unique taxonomic shifts (Faecalibacterium, Bacteroides, Fusicatenibacter, Erysipelotrichaceae UCG-003, and Subdoligranulum) over chemotherapy treatment compared to those without cognitive decline. Taken together, gut microbiome change was associated with cognitive decline during chemotherapy, independent of chemotherapy-induced inflammation. These results suggest that microbiome-related strategies may be useful for predicting and preventing behavioral side effects of chemotherapy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
28秒前
lingdu发布了新的文献求助10
34秒前
隐形曼青应助科研通管家采纳,获得10
36秒前
遍空应助科研通管家采纳,获得20
36秒前
orixero应助科研通管家采纳,获得10
36秒前
57秒前
yshj完成签到 ,获得积分10
1分钟前
ZYP完成签到,获得积分10
1分钟前
爆米花应助lin采纳,获得10
1分钟前
1分钟前
iso发布了新的文献求助10
2分钟前
小蘑菇应助iso采纳,获得10
2分钟前
2分钟前
iso完成签到,获得积分10
2分钟前
lingdu发布了新的文献求助10
2分钟前
科目三应助科研通管家采纳,获得10
2分钟前
科研通AI5应助科研通管家采纳,获得10
2分钟前
搜集达人应助lingdu采纳,获得10
2分钟前
3分钟前
lingdu发布了新的文献求助10
3分钟前
玉米完成签到,获得积分10
4分钟前
可爱的函函应助玉米采纳,获得10
4分钟前
lingdu发布了新的文献求助10
4分钟前
KINGAZX完成签到 ,获得积分10
4分钟前
街道办柏阿姨完成签到 ,获得积分10
4分钟前
5分钟前
洁净思枫发布了新的文献求助10
5分钟前
6分钟前
6分钟前
ffff完成签到 ,获得积分10
6分钟前
壹贰完成签到 ,获得积分10
6分钟前
6分钟前
6分钟前
胡萝卜完成签到,获得积分10
6分钟前
clearsky应助科研通管家采纳,获得10
6分钟前
852应助科研通管家采纳,获得10
6分钟前
量子星尘发布了新的文献求助10
6分钟前
7分钟前
7分钟前
拼搏的秋玲完成签到,获得积分20
7分钟前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Nuclear Fuel Behaviour under RIA Conditions 500
Sociologies et cosmopolitisme méthodologique 400
Why America Can't Retrench (And How it Might) 400
Another look at Archaeopteryx as the oldest bird 390
Parenchymal volume and functional recovery after clamped partial nephrectomy: potential discrepancies 300
Optimization and Learning via Stochastic Gradient Search 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 物理化学 基因 催化作用 遗传学 冶金 电极 光电子学
热门帖子
关注 科研通微信公众号,转发送积分 4682323
求助须知:如何正确求助?哪些是违规求助? 4057809
关于积分的说明 12545519
捐赠科研通 3753261
什么是DOI,文献DOI怎么找? 2072912
邀请新用户注册赠送积分活动 1101909
科研通“疑难数据库(出版商)”最低求助积分说明 981211