生物
神经嵴
解剖
乘客3
中胚层
骨骼肌
表型
间充质
胚胎干细胞
细胞生物学
遗传学
胚胎
基因
转录因子
作者
Ahmed Mansouri,A. Stoykova,Miguel Torres,Peter Gruß
出处
期刊:Development
[The Company of Biologists]
日期:1996-03-01
卷期号:122 (3): 831-838
被引量:301
标识
DOI:10.1242/dev.122.3.831
摘要
ABSTRACT Pax7 is a member of the paired box containing gene family. Its expression pattern suggests a function in cephalic neural crest derivatives, skeletal muscle and central nervous system development. To understand the role of Pax7 during mouse embryogenesis, we used the homologous recombination technique in embryonic stem cells and generated Pax7–/– mice. Homozygous animals are born but die shortly after weaning. They exhibit malformations in facial structures involving the maxilla and nose. Our analysis suggests that the observed phenotype is due to a cephalic neural crest defect. No obvious phenotype could be detected in the central nervous system and skeletal muscle. Functional redundancy between Pax7 and Pax3 is discussed.
科研通智能强力驱动
Strongly Powered by AbleSci AI