男性不育
多囊肾病
不育
常染色体显性多囊肾病
发病机制
医学
多囊卵巢
精子无力症
肾
生物
内科学
内分泌学
遗传学
怀孕
糖尿病
胰岛素抵抗
作者
Weihui Shi,Chenming Xu
出处
期刊:PubMed
日期:2018-09-01
卷期号:24 (9): 839-843
摘要
Polycystic kidney diseases (PKD) are inherited monogenetic disorders characterized by multiple progressive renal cysts, which can be divided into two types- autosomal dominant PKD (ADPKD) and autosomal recessive PKD (ARPKD). Although most of the male patients with PKD have normal fertility, some are reportedly infertile. Recent studies show that the reproductive disorders in PKD males are associated with such pathological changes as seminal vesicle cysts, asthenozoospermia, necrozoospermia, flagella structural abnormalities, and end-stage renal disease. Based on the results of current studies, this review focuses on the pathogenesis of male infertility in PKD patients in terms of the reproductive system structure and related genes and proteins, aiming for a further understanding of PKD.
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