膜
纳米技术
材料科学
药物输送
癌细胞
光热治疗
生物医学工程
涂层
靶向给药
癌症治疗
癌症
化学
医学
生物化学
内科学
作者
Dao‐Lin Wang,Changyong Gao,Chang Zhou,Zhihua Lin,Qiang He
出处
期刊:Research
[AAAS00]
日期:2020-01-01
卷期号:2020
被引量:73
标识
DOI:10.34133/2020/3676954
摘要
We report a leukocyte membrane-coated gallium nanoswimmer (LMGNS) capable of ultrasound-propelled motion, antibiofouling, and cancer cell recognition and targeting. The LMGNS consists of a needle-shaped gallium core encapsulating an anticancer drug and a natural leukocyte membrane shell. Under the propulsion of an ultrasound field, LMGNSs could autonomously move in biological media with a speed up to 108.7 μm s-1. The velocity and motion direction of the LMGNSs can be modulated by regulating the frequency and voltage of the applied ultrasound field. Owing to the leukocyte membrane coating, LMGNSs can not only avoid biofouling during the motion in blood but also possess cancer cell recognition capability. These LMGNSs could actively seek, penetrate, and internalize into the cancer cells and achieve enhanced anticancer efficiency by combined photothermal and chemical therapy. Such biofunctionalized liquid metal nanoswimmer presents a new type of multifunctional platform for biomedical applications.
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