Oculoleptomeningeal Amyloidosis Due to Transthyretin p.Y89H (Y69H) Variant

To the Editor:Oculoleptomeningeal amyloidosis (OLMA) represents a rare subtype of familial transthyretin (TTR) amyloidosis, an autosomal dominant phenotype of familial amyloidosis characterized by deposition of amyloid in cranial and spinal leptomeninges along with ocular involvement.Here, we describe a case of leptomeningeal amyloidosis associated with the ATTRY89H (Y69H) mutation, linking this variant in the OLMA phenotype.A 37-year-old Brazilian man presented with a 4-year history of recurring neurologic symptoms including progressive right-sided body tingling and weakness associated with tension-type headache, mental confusion, and aphasia lasting 2-8 hours.Complete neurological recovery occurred after these episodes.In 2018, during a full neurological investiga-