Injectable antibacterial antiinflammatory molecular hybrid hydrogel dressing for rapid MDRB-infected wound repair and therapy

Abstract Multidrug resistant-bacteria (MDRB) impaired wound repair and regeneration remains a critical challenge. The development of multifunctional bioactive dressing with excellent wound healing and MDRB treating ability could probably address this problem. Herein, we developed an injectable multifunctional poly (citrate-glycol-siloxane)-based (PCGS) molecular hybrid hydrogel dressing for treating MDRB infection and enhancing wound healing. The PCGS-based hydrogel dressing possesses good injectability, controlled mechanical properties, temperature-responsive sol–gel behavior, broad-spectrum antibacterial activity including against MDRB (>99.99%). This dressing demonstrated the excellent cytocompatibility and could significantly enhance the activity of fibroblasts proliferation and migration of endothelial cells. The in vivo studies showed that PCGS-based dressing could significantly inhibit the MDRB infection on wound and promote the wound healing and skin appendage construction through reinforcing the early angiogenesis and decreasing the infection-derived inflammation. Our study suggests that PCGS-based hydrogel dressing with inorganic–organic hybrid structure at molecular level would have the promising potential in treating MDRB-infected wound and skin repair.