Hypertonic solution does not decrease the mortality of severe brain injury: a systemic review and a meta-analysis based on randomized control trials

Objective To systematically evaluate whether administration of hypertonic solution transfusion affects clinical outcomes in the early stage of resuscitation for severe brain injury patients. Methods Six English and Chinese biomedicine databases were searched for randomized controlled trials( RCTs) published from January 2003 to September 2013. The inclusion and exclusion criteria were established to evaluate these RCTs. The quality assessment was based on the Cochrane Handbook for Systematic Reviews of Interventions Version 5. 0. 1 and Jadad scored scale. RevMan 5. 2 statistical software was used for meta-analysis. Results After evaluating 34 related literatures,four RCTs met all the inclusion criteria and were enrolled for meta-analysis. The meta-analysis demonstrated that early hypertonic transfusion administration did not decrease mortality( OR = 0. 94,P = 0. 56). It also did not decrease the total length of stay in the hospital( MD =-0. 45,P = 0. 90). Conclusion Compared to conventional fluid resuscitation strategy,hypertonic solution does not improve the mortality of severe brain injury. Also,it cannot reduce the total time in hospital stay.