Relationship of cytokine level with cancer cachexia and its clinical research

Objective To study the expression of cytokine in the cancer cachexia patients and to discuss the relationship with cancer cachexia.Methods To compare the IL-1、IL-6、TNF-α、IFN-γ levels with 80 cases patients of cancer cachexia、40 cases healthy people and 40 cases patients of non-cancer cachexia.To oral medroxyprogesterone with the 80 cases patients of cancer cachexia and give the nutritional support of four weeks.Four weeks later,to detect the levels of IL-1、IL-6、TNF-α、IFN-γand compare with pre-treatment.Results Compared cancer cachexia group with non-cancer cachexia group and healthy group,the levels of IL-1、IL-6、TNF-α、IFN-γ increased.P0.05,there were significances in statistics;The 80 cases patients of cancer cachexia through four weeks treated,the levels of IL-1、IL-6、TNF-α、IFN-γ decreased.P0.05,there were significances in statistics.Conclusion Cytokines are relevant to the cancer cachexia and playing an important role.