免疫原性
结合
抗原
生物
肽
受体
癌症疫苗
配体(生物化学)
接种疫苗
免疫系统
免疫疗法
免疫学
生物化学
数学分析
数学
作者
Gijs G. Zom,Selina Khan,Dmitri V. Filippov,Ferry Ossendorp
出处
期刊:Advances in Immunology
日期:2012-01-01
卷期号:: 177-201
被引量:73
标识
DOI:10.1016/b978-0-12-396548-6.00007-x
摘要
Approaches to treat cancer with therapeutic vaccination have made significant progress. In order to induce efficient antitumor immunity, a vaccine should target and activate antigen-presenting cells, such as the dendritic cell, while delivering the tumor-derived antigen of choice. Conjugates of synthetic peptides and ligands of pattern-recognition receptors (PRRs) combine these features and, given their synthetic nature, can be produced under GMP conditions. Therefore, conjugation of antigenic peptides to potent PRR ligands is a promising vaccination approach for the treatment of cancer. This review focuses on the different PRR families that can be exploited for the design of conjugates and explores the results obtained so far with PRR ligands conjugated to antigen. The uptake and processing of Toll-like receptor ligand–peptide conjugates are discussed in more detail, as well as future directions that may further enhance the immunogenicity of conjugates.
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