Hypothalamic Control of Energy Homeostasis

The hypothalamus has long been known to be involved in the control of energy homeostasis and metabolism by acting as a key integrator and transducer of central and peripheral hormonal and nutritional inputs [1] [2]. The 12 articles in this Special Issue review and discuss different aspects of the central regulation of whole-body energy metabolism, from the hypothalamic circuitries and molecular pathways involved in the regulation of food intake, energy expenditure, and glucose homeostasis, to the increasing number of peripheral metabolic signals that inform the central nervous system (CNS) on the body energy status, and the emerging role of novel actors mediating the hypothalamic response to metabolic challenges.