疾病
神经毒性
脑病
医学
神经科学
毒性
贫血
生物利用度
生理学
生物信息学
药理学
生物
病理
内科学
作者
María Teresa Colomina,Fiona Peris‐Sampedro
出处
期刊:Advances in neurobiology
日期:2017-01-01
卷期号:: 183-197
被引量:87
标识
DOI:10.1007/978-3-319-60189-2_9
摘要
Aluminum (Al) is one of the most extended metals in the Earth’s crust. Its abundance, together with the widespread use by humans, makes Al-related toxicity particularly relevant for human health. Despite some factors influence individual bioavailability to this metal after oral, dermal, or inhalation exposures, humans are considered to be protected against Al toxicity because of its low absorption and efficient renal excretion. However, several factors can modify Al absorption and distribution through the body, which may in turn progressively contribute to the development of silent chronic exposures that may lately trigger undesirable consequences to health. For instance, Al has been recurrently shown to cause encephalopathy, anemia, and bone disease in dialyzed patients. On the other hand, it remains controversial whether low doses of this metal may contribute to developing Alzheimer’s disease (AD), probably because of the multifactorial and highly variable presentation of the disease. This chapter primarily focuses on two key aspects related to Al neurotoxicity and AD, which are metabolic impairment and iron (Fe) alterations. We discuss sex and genetic differences as a plausible source of bias to assess risk assessment in human populations.
科研通智能强力驱动
Strongly Powered by AbleSci AI