Comparison of the percentages of CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs, in the umbilical cord blood of babies born to mothers with and without preeclampsia

Problem Little is known about how preeclampsia affects regulatory T‐cell count and functions in umbilical cord blood of babies born to preeclamptic mothers. Here, we analyze the percentage of CD 4 + CD 25 high FOXP 3 + , CD 4 + CD 25 low FOXP 3 + , and CD 4 + FOXP 3 + Tregs, in the umbilical cord blood of babies born to mothers with and without preeclampsia. Method of study The percentage of umbilical cord blood CD 4 + CD 25 high FOXP 3 + , CD 4 + CD 25 low FOXP 3 + , and CD 4 + FOXP 3 + Tregs were analyzed by flow cytometry. Results CD 4 + CD 25 high FOXP 3 + Treg (%) and CD 4 + FOXP 3 + Treg (%) were significantly lower, while CD 4 + CD 25 low (%) was significantly higher in umbilical cord blood of babies born to preeclamptic mothers. Conclusion Preeclampsia is associated with immune dysregulation which leads to a deficiency in Treg ( CD 4 + CD 25 high FOXP 3 + ) in the umbilical cord blood of babies born to preeclamptic mothers.