DNA甲基化
生物
癌症
表观遗传学
癌细胞
癌症研究
表观遗传学
肿瘤微环境
癌症干细胞
癌相关成纤维细胞
细胞生物学
间质细胞
遗传学
基因
基因表达
作者
Masahiro Maeda,Hideyuki Takeshima,Naoko Iida,Naoko Hattori,Satoshi Yamashita,Hiroshi Moro,Yoshimi Yasukawa,Kazuhiro Nishiyama,Taiki Hashimoto,Shigeki Sekine,Genichiro Ishii,Atsushi Ochiai,Takeo Fukagawa,Hitoshi Katai,Yoshiharu Sakai,Toshikazu Ushijima
出处
期刊：Gut
[BMJ]
日期：2019-05-13
卷期号：69 (2): 243-251
被引量：114
标识
DOI：10.1136/gutjnl-2018-317645
摘要
H3K27me3 plays a crucial role in defining tumour-promoting capacities of CAFs, and multiple stem cell niche factors were secreted from CAFs due to loss of H3K27me3. The validity of the epigenetic approach to uncover therapeutic targets for cancer-starving therapy was demonstrated.
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