医学
神经肌肉疾病
超声波
束状
肌肉活检
肌肉僵硬
物理医学与康复
疾病
肌肉疾病
肌萎缩侧索硬化
肌病
弹性成像
放射科
病理
活检
解剖
内科学
刚度
结构工程
工程类
作者
Nens van Alfen,Kaj Gijsbertse,Chris L. de Korte
标识
DOI:10.1097/wco.0000000000000589
摘要
Purpose of review This review focuses on developments in muscle ultrasound as a noninvasive and accurate tool for the diagnosis and follow-up of neuromuscular disease. It discusses current muscle ultrasound applications with already proven clinical value, and highlights recent technical developments that may further advance muscle ultrasounds’ diagnostic qualities. Recent findings The sensitivity and specificity of muscle ultrasound for detecting a neuromuscular disorder are high (90–95%), and quantitative ultrasound is well suited to monitor disease progression in several disorders. Adding ultrasound to electromyography significantly improves diagnostic certainty in patients with suspected motor neuron disease, and ultrasound increases the detection of fasciculations with 30–50%. New developments include speckle tracking of tissue motion to quantify diaphragm excursions and diminished muscle contractility in dystrophy, and strain elastography to detect changes in muscle stiffness and anisotropy during contraction and in disease states. Deep learning algorithms are being developed to predict the presence of a muscle disease and differentiate between disorders. Summary Muscle ultrasound is excellent for screening, diagnosing, and follow-up of neuromuscular disease. New developments are underway to automate and objectify the diagnostic process, and to quantify tissue motion that can provide new insights in pathophysiology and serve as a biomarker.
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